Electronegative LDL from Rabbits Fed with Atherogenic Diet Is Highly Proinflammatory
نویسندگان
چکیده
منابع مشابه
Oral administration of a turmeric extract inhibits erythrocyte and liver microsome membrane oxidation in rabbits fed with an atherogenic diet.
OBJECTIVES The aim of this study was to evaluate the effects of an oral supplementation with a Curcuma longa ethanol and aqueous extract on the susceptibility to oxidation of cellular and subcellular membranes affected in the atherosclerotic process, such as erythrocyte membranes and liver microsomes, in rabbits fed with a high-fat diet. METHODS Twenty-four male rabbits were randomly assigned...
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Male adult rabbits were divided into five experimental groups and were fed a 2% cholesterol diet using the following schedule: (A) two groups, normal control diet; (B) one group, 60 days continuous diet (60 day); (C) one group, 30 days cholesterol 30 days control diet (3030); (D) one group, 60 days cholesterol, 30 days control diet (60-30). Aortic collagen synthesis was estimated by measuring t...
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Rabbits fed low-fat, cholesterol-free diets containing casein as the sole protein source develop endogenous hypercholesterolemia (EH). To test the hypothesis that lipoprotein cholesteryl esters in EH rabbits are acyl coenzyme A:cholesterol acyltransferase (ACAT) derived, we treated EH rabbits with CI-976, a potent and selective ACAT inhibitor. In addition, since cholesterol and bile acid synthe...
متن کاملatherogenic diet
We studied the effect of propranolol on the diet-induced coronary artery atherosclerosis (CAA) in 30 adult male cynomolgus monkeys living in social groupings of five animals each. Animals in the "treated" segment (n = 15) consumed propranolol, which was mixed into an atherogenic diet. Animals in the "untreated" group (n = 15) consumed only the atherogenic diet. Finally, the social groupings wer...
متن کاملCeramide-enriched LDL induces cytokine release through TLR4 and CD14 in monocytes. Similarities with electronegative LDL.
INTRODUCTION In vitro ceramide-enriched LDL (CER-LDL) reproduces most of the properties of electronegative LDL (LDL(-)), a heterogeneous subfraction of LDL found in plasma. LDL(-) comprises several modifications of LDL and has an increased content in ceramide (CER). It promotes cytokine release in monocytes through CD14 and TLR4. CER-LDL also induces cytokine release in these cells but the mech...
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ژورنال
عنوان ژورنال: Mediators of Inflammation
سال: 2019
ISSN: 0962-9351,1466-1861
DOI: 10.1155/2019/6163130